L-DOPA Treatment Selectively Restores Spine Density in Dopamine Receptor D2–Expressing Projection Neurons in Dyskinetic Mice

@article{Suarez2014LDOPATS,
  title={L-DOPA Treatment Selectively Restores Spine Density in Dopamine Receptor D2–Expressing Projection Neurons in Dyskinetic Mice},
  author={Luz M Suarez and Oscar Sol{\'i}s and Jos{\'e} Mar{\'i}a Caram{\'e}s and Irene R. E. Taravini and Jos{\'e}M. Sol{\'i}s and Mario Gustavo Murer and Rosario Moratalla},
  journal={Biological Psychiatry},
  year={2014},
  volume={75},
  pages={711-722}
}
BACKGROUND L-3,4-dihydroxyphenylalanine (L-DOPA)-induced dyskinesia is an incapacitating complication of L-DOPA therapy that affects most patients with Parkinson's disease. Previous work indicating that molecular sensitization to dopamine receptor D1 (D1R) stimulation is involved in dyskinesias prompted us to perform electrophysiological recordings of striatal projection "medium spiny neurons" (MSN). Moreover, because enhanced D1R signaling in drug abuse induces changes in spine density in… CONTINUE READING
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