L-DOPA: From a biologically inactive amino acid to a successful therapeutic agent

@article{Hornykiewicz2002LDOPAFA,
  title={L-DOPA: From a biologically inactive amino acid to a successful therapeutic agent
},
  author={O. Hornykiewicz},
  journal={Amino Acids},
  year={2002},
  volume={23},
  pages={65-70}
}
  • O. Hornykiewicz
  • Published 2002
  • Biology, Medicine
  • Amino Acids
  • Summary. The article traces the development of research on the naturally occurring amino acid L-3,4-dihydroxyphenylalanine (L-dopa), from the first synthesis of its D,L racemate in 1911, and the isolation of its L-isomer from seedling of Vicia faba beans to the amino acid's successful application, from 1961 onward, as the most efficacious drug treatment of Parkinson's disease (PD). Upon its isolation from legumes in 1913, L-dopa was declared to be biologically inactive. However, two early… CONTINUE READING
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