• Corpus ID: 198351660

L-Carnosine alleviates cadmium induced disruption of K-Cadherin /Catenin/ Wnt signaling in human renal proximal tubule epithelial cells

@inproceedings{Silva2017LCarnosineAC,
  title={L-Carnosine alleviates cadmium induced disruption of K-Cadherin /Catenin/ Wnt signaling in human renal proximal tubule epithelial cells},
  author={Nuno Silva and Mark Edward Carl Dockrell},
  year={2017}
}
Introduction: Nephrotoxin cadmium (Cd) is a common environmental pollutant associated with chronic kidney disease (CKD) characterized by interstitial fibrosis. Cadmium activates wnt/β catenin signaling pathway while aberrant wnt activation is implicated in fibrosis. Dipeptide L-carnosine is known to mitigate detrimental effects of metal compounds on mammalian cells. Objectives: Objective was to demonstrate that L-carnosine is capable of alleviating activation of wnt/ β catenin signaling pathway…