L-Carnitine treatment reduces severity of physical and mental fatigue and increases cognitive functions in centenarians: a randomized and controlled clinical trial.

@article{Malaguarnera2007LCarnitineTR,
  title={L-Carnitine treatment reduces severity of physical and mental fatigue and increases cognitive functions in centenarians: a randomized and controlled clinical trial.},
  author={Mariano Malaguarnera and Lisa Cammalleri and Maria Pia Gargante and Marco Vacante and Valentina Colonna and Massimo Motta},
  journal={The American journal of clinical nutrition},
  year={2007},
  volume={86 6},
  pages={1738-44}
}
BACKGROUND Centenarians are characterized by weakness, decreasing mental health, impaired mobility, and poor endurance. L-Carnitine is an important contributor to cellular energy metabolism. OBJECTIVE This study evaluated the efficacy of L-carnitine on physical and mental fatigue and on cognitive functions of centenarians. DESIGN This was a placebo-controlled, randomized, double-blind, 2-phase study. Sixty-six centenarians with onset of fatigue after even slight physical activity were… CONTINUE READING

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