L-Carnitine transport in mouse renal and intestinal brush-border and basolateral membrane vesicles.

@article{Lahjouji2002LCarnitineTI,
  title={L-Carnitine transport in mouse renal and intestinal brush-border and basolateral membrane vesicles.},
  author={Karim Lahjouji and Christiane Malo and Grant A Mitchell and Ijaz A. Qureshi},
  journal={Biochimica et biophysica acta},
  year={2002},
  volume={1558 1},
  pages={
          82-93
        }
}

Figures from this paper

L-Carnitine transport in human placental brush-border membranes is mediated by the sodium-dependent organic cation transporter OCTN2.

OCTN2, a high-affinity, Na(+)-dependent carnitine transporter, was present in placental BBM but not in isolated basal plasma membrane vesicles, suggesting that OCTN2 may mediate most maternofetal carnitines transport in humans.

Expression and localization of organic cation/carnitine transporter OCTN2 in Caco-2 cells.

The results demonstrate that l-carnitine uptake in differentiated Caco-2 cells is primarily mediated by OCTN2, located on the BBM.

Organic Cation/Carnitine Transporter OCTN2 (Slc22a5) Is Responsible for Carnitine Transport across Apical Membranes of Small Intestinal Epithelial Cells in Mouse

Findings indicate that OCTN2 is predominantly responsible for the uptake of carnitine from the apical surface of mouse small intestinal epithelial cells, and it may therefore be a promising target for oral delivery of therapeutic agents that are OCTn2 substrates.

The renal-specific transporter mediates facilitative transport of organic anions at the brush border membrane of mouse renal tubules.

It is suggested that mouse RST mediates the efflux of organic anions including urate and works as exit for organicAnions in the proximal tubules and may also play a role in efflux transport oforganic anions across the barriers of the central nervous system.

Expression and localization of organic cation / carnitine transporter OCTN 2 in Caco-2 cells

It is demonstrated that L-carnitine uptake in differentiated Caco-2 cells is primarily mediated by OCTN2, located on the BBM, which was confirmed by double immunostaining.

Expression of OCTN2 and OCTN3 in the apical membrane of rat renal cortex and medulla

This is the first report showing a functional apical OCTN2 in the renal medulla and a functional APical OCTn3 in both renal cortex and medulla, indicating that OCTN3 can function as an L‐carnitine/organic compound exchanger.

Localization of organic cation/carnitine transporter (OCTN2) in cells forming the blood–brain barrier

Localization of OCTN2 suggest that carnitine can be also transported from the brain, playing an important role in removal of certain acyl esters.

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