L-Carnitine transport in human placental brush-border membranes is mediated by the sodium-dependent organic cation transporter OCTN2.

@article{Lahjouji2004LCarnitineTI,
  title={L-Carnitine transport in human placental brush-border membranes is mediated by the sodium-dependent organic cation transporter OCTN2.},
  author={Karim Lahjouji and Ihsan Elimrani and Julie Lafond and Line Leduc and Ijaz A. Qureshi and Grant A Mitchell},
  journal={American journal of physiology. Cell physiology},
  year={2004},
  volume={287 2},
  pages={
          C263-9
        }
}
Maternofetal transport of l-carnitine, a molecule that shuttles long-chain fatty acids to the mitochondria for oxidation, is thought to be important in preparing the fetus for its lipid-rich postnatal milk diet. Using brush-border membrane (BBM) vesicles from human term placentas, we showed that l-carnitine uptake was sodium and temperature dependent, showed high affinity for carnitine (apparent K(m) = 11.09 +/- 1.32 microM; V(max) = 41.75 +/- 0.94 pmol.mg protein(-1).min(-1)), and was… 

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