L-Carnitine inhibits protein glycation in vitro and in vivo: evidence for a role in diabetic management

  title={L-Carnitine inhibits protein glycation in vitro and in vivo: evidence for a role in diabetic management},
  author={Panchamoorthy Rajasekar and Carani Venkataraman Anuradha},
  journal={Acta Diabetologica},
Glycation-initiated changes in tissue proteins are suggested to play an important role in the development of diabetes-related pathological changes. The purpose of this study was to examine the anti-glycating effect of L-carnitine (CA) in vivo in the high-fructose diet-fed rat and to determine the potential of CA to inhibit in vitro glycation. Additionally the glucose-disposal efficiency of CA in the rat diaphragm was investigated. High-fructose diet (60 g/100 g diet)-fed rats were treated with… CONTINUE READING
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L-Carnitine administration prevents oxidative stress in high fructose-fed insulin resistant rats

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