L-Carnitine attenuates angiotensin II-induced proliferation of cardiac fibroblasts: role of NADPH oxidase inhibition and decreased sphingosine-1-phosphate generation.

@article{Chao2010LCarnitineAA,
  title={L-Carnitine attenuates angiotensin II-induced proliferation of cardiac fibroblasts: role of NADPH oxidase inhibition and decreased sphingosine-1-phosphate generation.},
  author={Hung-Hsin Chao and Cheng-hsien Chen and Ju-Chi Liu and Jia-Wei Lin and Kar-lok Wong and Tzu-Hurng Cheng},
  journal={The Journal of nutritional biochemistry},
  year={2010},
  volume={21 7},
  pages={580-8}
}
The heart is unable to synthesize L-carnitine and is strictly dependent on the L-carnitine provided by the blood stream; however, additional studies are needed to better understand the mechanism of L-carnitine supplementation to the heart. The aim of this study was to evaluate the effects of L-carnitine on angiotensin II (Ang II)-induced cardiac fibroblast proliferation and to explore its intracellular mechanism(s). Cultured rat cardiac fibroblasts were pretreated with L-carnitine (1-30 mM… CONTINUE READING

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