L-Carnitine ameliorates methotrexate-induced oxidative organ injury and inhibits leukocyte death

@article{ener2006LCarnitineAM,
  title={L-Carnitine ameliorates methotrexate-induced oxidative organ injury and inhibits leukocyte death},
  author={G{\"o}ksel Şener and Emel Ekşioğlu-Demiralp and Mustafa Çetiner and Feriha Ercan and Serap Sirvancı and Nursal Gedik and Berrak Ç. Yeğen},
  journal={Cell Biology and Toxicology},
  year={2006},
  volume={22},
  pages={47-60}
}
Methotrexate (MTX), a folic acid antagonist widely used for the treatment of a variety of tumors and inflammatory diseases, affects normal tissues that have a high rate of proliferation, including the hematopoietic cells of the bone marrow and the gastrointestinal mucosal cells. To elucidate the role of free radicals and leukocytes in MTX-induced oxidative organ damage and the putative protective effect of L-carnitine (L-Car), Wistar albino rats were administered a single dose of MTX (20 mg/kg… Expand
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