L-Carnitine Protection Against Cisplatin Nephrotoxicity In Rats: Comparison with Amifostin Using Quantitative Renal Tc 99m DMSA Uptake

@article{Yrekli2011LCarnitinePA,
  title={L-Carnitine Protection Against Cisplatin Nephrotoxicity In Rats: Comparison with Amifostin Using Quantitative Renal Tc 99m DMSA Uptake},
  author={Yakup Y{\"u}rekli and Perihan {\"U}nak and Çiğdem Yenisey and T{\"u}rkan Ertay and Fazilet Z{\"u}mr{\"u}t Biber M{\"u}ft{\"u}ler and Emin Ilker Medine},
  journal={Molecular Imaging and Radionuclide Therapy},
  year={2011},
  volume={20},
  pages={1 - 6}
}
Objective: In this study, we aimed to investigate the cytoprotective effect of L-carnitine against cisplatin-induced nephrotoxicity and to compare its efficacy with that of amifostin by quantitative renal Tc 99m DMSA uptake. Material and Methods: Male Wistar rats were randomly divided into six groups of six animals each. 1) Control (saline; 5 ml/kg intraperitoneally); 2) L-carnitine (CAR; 300 mg/kg intraperitoneally); 3) Amifostine (AMI; 200 mg /kg intraperitoneally); 4) Cisplatin (CIS;7 mg/kg… 

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