L-Carnitine Protection Against Cisplatin Nephrotoxicity In Rats: Comparison with Amifostin Using Quantitative Renal Tc 99m DMSA Uptake

  title={L-Carnitine Protection Against Cisplatin Nephrotoxicity In Rats: Comparison with Amifostin Using Quantitative Renal Tc 99m DMSA Uptake},
  author={Yakup Y{\"u}rekli and Perihan {\"U}nak and Çiğdem Yenisey and T{\"u}rkan Ertay and Fazilet Z{\"u}mr{\"u}t Biber M{\"u}ft{\"u}ler and Emin Ilker Medine},
  journal={Molecular Imaging and Radionuclide Therapy},
  pages={1 - 6}
Objective: In this study, we aimed to investigate the cytoprotective effect of L-carnitine against cisplatin-induced nephrotoxicity and to compare its efficacy with that of amifostin by quantitative renal Tc 99m DMSA uptake. Material and Methods: Male Wistar rats were randomly divided into six groups of six animals each. 1) Control (saline; 5 ml/kg intraperitoneally); 2) L-carnitine (CAR; 300 mg/kg intraperitoneally); 3) Amifostine (AMI; 200 mg /kg intraperitoneally); 4) Cisplatin (CIS;7 mg/kg… 

Figures and Tables from this paper

Protective effects of thymol against nephrotoxicity induced by cisplatin with using 99mTc-DMSA in mice

It is shown that thymol significantly attenuates the cisplatin-induced nephrotoxicity in mice, and 99mTc-DMSA uptake in kidney is a suitable method for assessment of neph rotoxin in mice.

Evaluation of the protective effect of edaravone on doxorubicin nephrotoxicity by [99mTc]DMSA renal scintigraphy and biochemical methods

Edaravone has a significant nephroprotective effect through the attenuation of oxidative stress and inflammatory markers during doxorubicin-induced nephrotoxicity in rats.

Ameliorative Effect of L-Carnitine on Renal Function and Oxidative Stress in Cancer Patients with Cisplatin-Induced Nephrotoxicity

L-carnitine significantly ameliorated nephrotoxicity in patients receiving cisplatin primarily by inhibiting renal oxidative stress, and this study found this to be a major dose-limiting side effect facing cisPlatin-based chemotherapy of a wide variety of cancers.

L-Carnitine Mitigates Oxidative Stress and Disorganization of Cytoskeleton Intermediate Filaments in Cisplatin-Induced Hepato-Renal Toxicity in Rats

LC may be supplemented for chemotherapy with CP to ameliorate its oxidative stress and restore the normal organization of IFs, especially VIM and CK18 within the CP intoxicated hepato-renal cells.

Effect of L Carnitine against Mercuric Chloride-Induced Nephrotoxicity

Pretreatment of rats with CAR resulted in a complete reversal of Hg-induced increase in creatinine and BUN to control values, indicating that AG is an efficient cytoprotective agent against HG-induced nephrotoxicity.

L-carnitine suppresses cisplatin-induced renal injury in rats: impact on cytoskeleton proteins expression.

It is concluded that LCAR has a favorable therapeutic utility against CDDP-induced kidney injury and effectively down-regulated cytoskeleton proteins mRNA levels, reflecting amelioration ofCDDP-provoked podocyte injury.

The effects of carvedilol, metoprolol and propranolol on cisplatin-induced kidney injury

Both low and high -doses of carvedilol significantly inhibited cisplatin effects on kidney histology, BUN and creatinine levels, and high-dose propranolol inhibited cisPlatin adverse effects on radiotracer uptake, histological manifestations, B UN and Creatinine Levels, while metoprolol failed to cause a notable effect.

The Screening of Renoprotective Agents by 99mTc-DMSA: A Review of Preclinical Studies.

In this review, the recent findings about the renoprotective agents were evaluated and screened with respect to the use of 99mTc-DMSA, which is preclinically and clinically used for animal cases and cancer patients under the treatment by radiotherapy and chemotherapy.



Protective effect of l-carnitine versus amifostine against cisplatin-induced nephrotoxicity in rats

It is suggested that application of AMF before CDDP may enhance CDDP-induced nephrotoxicity histopathologically and not have a protective effect on AMF or CAR.

Progression of Cisplatin-Induced Nephrotoxicity in a Carnitine-Depleted Rat Model

Data from this study suggest that oxidative stress plays an important role in cisplatin-induced kidney damage; carnitine deficiency should be viewed as an additional risk factor and/or a mechanism in cisPlatin- induced renal dysfunction, and L-carnitine supplementation attenuates cisplarin-induced renal dysfunction.

Evaluation of the Effect of Acetyl L-Carnitine on Experimental Cisplatin Nephrotoxicity

Antioxidative, antiapoptotic and anti-inflammatory properties of ALCAR were supported by the findings that this agent improves kidney function tests and has the effects of tissue protection and inhibition of apoptosis in cisplatin-induced nephrotoxicity.


Based on the results of the present study, l‐carnitine and amifostine have comparable and significant protective effects against radiation‐induced late nephrotoxicity.

Tiopronin protects against the nephrotoxicity of cisplatin in the rat

Oral administration of tiopronin may be a clinically useful way to prevent cisplatin nephrotoxic effects in rats in vivo, and the results show that tiopronsin protects against cis platin-induced neph rotoxicity.

Paclitaxel and Cisplatin-induced neurotoxicity: a protective role of acetyl-L-carnitine.

It is indicated that ALC is a specific protective agent for chemotherapy-induced neuropathy after cisplatin or paclitaxel treatment without showing any interference with the antitumor activity of the drugs.

Cisplatin Nephrotoxicity: A Review

Understanding the mechanisms of injury has led to multiple approaches to prevention and potential approaches to treatment and the experimental approaches in these studies with cisplatin are potentially applicable to other drugs causing renal dysfunction.