• Corpus ID: 6509192

L-Carnitine: therapeutic applications of a conditionally-essential amino acid.

@article{Kelly1998LCarnitineTA,
  title={L-Carnitine: therapeutic applications of a conditionally-essential amino acid.},
  author={Gregory S. Kelly},
  journal={Alternative medicine review : a journal of clinical therapeutic},
  year={1998},
  volume={3 5},
  pages={
          345-60
        }
}
  • G. Kelly
  • Published 1 October 1998
  • Medicine, Biology
  • Alternative medicine review : a journal of clinical therapeutic
A trimethylated amino acid roughly similar in structure to choline, carnitine is a cofactor required for transformation of free long-chain fatty acids into acylcarnitines, and for their subsequent transport into the mitochondrial matrix, where they undergo beta-oxidation for cellular energy production. Mitochondrial fatty acid oxidation is the primary fuel source in heart and skeletal muscle, pointing to the relative importance of this nutrient for proper function in these tissues. Although L… 

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Pharmacokinetics of L-Carnitine

The renal clearance of L-carnitine increases after exogenous administration, approaching GFR after high intravenous doses, and many forms of secondary carnitine deficiency, including some drug-induced disorders, arise from impaired renal tubular re absorption.

Carnitine and Acylcarnitines

Previous research associated with the homeostasis and pharmaco-kinetics of L-carnitine and its esters are examined, and potential areas of future research are highlighted, to adequately characterize metabolic status.

L-Carnitine Ameliorates Oxidative Damage due to Chronic Renal Failure in Rats

L-carnitine, possibly via its free radical scavenging and antioxidant properties, ameliorates oxidative organ injury and CRF-induced dysfunction of the aorta and corpus cavernosum and suggests that L-c Carnitine supplementation may have some benefit in CRF patients.

[Role of L-carnitine in metabolism, nutrition and therapy].

L-carnitine plays an important role in the translocation of acetyl moieties from the mitochondria to the cytoplasm for acetylcholine synthesis in neurones and other roles--include removal of excess acyl groups, peroxisomal fatty-acid oxidation, and antioxidant activity.

Acetyl‐l‐carnitine for the Treatment of HIV Lipoatrophy

Carnitine supplementation for this antiretroviral toxicity is reviewed, and the available data from several small studies are inconclusive, although further research into this promising agent is warranted.

The Role of Carnitine in the Male Reproductive System

Research to uncover the many characteristics and mechanisms of action of carnitine in somatic and germ cells may provide insights into the pathophysiology of germ cell apoptosis, the prevention of germcell death, and possibly specific therapy of some forms of infertility.

Antimicrobial efficacy of L-carnitine

At these concentrations L-carnitine chloride can possibly be used as a safe local antimicrobial agent and could also contribute to the maintenance of a pathogen free environment.

An Overview of the Dietary Ingredient Carnitine

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References

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Carnitine and Physical Exercise

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  • A. LenziF. LombardoL. GandiniF. Dondero
  • Biology
    Archivio italiano di urologia, nefrologia, andrologia : organo ufficiale dell'Associazione per la ricerca in urologia = Urological, nephrological, and andrological sciences
  • 1992
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