L-BLP25: a peptide vaccine strategy in non small cell lung cancer.

  title={L-BLP25: a peptide vaccine strategy in non small cell lung cancer.},
  author={Randeep S. Sangha and Charles Andrew Butts},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  volume={13 15 Pt 2},
MUC1 is a mucinous glycoprotein which is overexpressed and under or aberrantly glycosylated in many human malignancies. MUC1 is associated with cellular transformation and can confer resistance to genotoxic agents. L-BLP25 is a peptide vaccine strategy that targets the exposed core peptide of MUC1. In preclinical studies, L-BLP25 induced a cellular immune response characterized by T-cell proliferation in response to MUC1 and production of IFN-gamma. Phase I and II trials have established the… CONTINUE READING
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