L-Arginine currents in rat cardiac ventricular myocytes.

  title={L-Arginine currents in rat cardiac ventricular myocytes.},
  author={R. Daniel Peluffo},
  journal={The Journal of physiology},
  volume={580 Pt.3},
L-Arginine (L-Arg) is a basic amino acid that plays a central role in the biosynthesis of nitric oxide, creatine, agmantine, polyamines, proline and glutamate. Most tissues, including myocardium, must import L-Arg from the circulation to ensure adequate intracellular levels of this amino acid. This study reports novel L-Arg-activated inward currents in whole-cell voltage-clamped rat ventricular cardiomyocytes. Ion-substitution experiments identified extracellular L-Arg as the charge-carrying… CONTINUE READING