L-Arginine administration prevents reperfusion-induced cardiomyocyte hypercontracture and reduces infarct size in the pig.

Abstract

OBJECTIVE Stimulation of cGMP synthesis protects cardiomyocytes against reoxygenation-induced hypercontracture. The purpose of this study was to determine whether L-arginine supplementation has a protective effect against reperfusion-induced hypercontracture and necrosis in the intact animal. METHODS Twenty-four Large-White pigs were randomized to receive… (More)

Topics

Cite this paper

@article{Padilla2000LArginineAP, title={L-Arginine administration prevents reperfusion-induced cardiomyocyte hypercontracture and reduces infarct size in the pig.}, author={Fernando Padilla and David Garcia-Dorado and Loreine Agull{\'o} and Javier Inserte and A. E. Paniagua and S{\`o}nia Mirabet and Jos{\'e} Antonio Barrab{\'e}s and Marisol Ruiz-Meana and Jordi Soler-Soler}, journal={Cardiovascular research}, year={2000}, volume={46 3}, pages={412-20} }