L-Arginine, a precursor of EDRF in vitro, produces pulmonary vasodilation in lambs.

@article{Fineman1991LArginineAP,
  title={L-Arginine, a precursor of EDRF in vitro, produces pulmonary vasodilation in lambs.},
  author={Jeffrey R. Fineman and R Chang and Scott J. Soifer},
  journal={The American journal of physiology},
  year={1991},
  volume={261 5 Pt 2},
  pages={
          H1563-9
        }
}
There is increasing evidence that resting pulmonary vascular tone is mediated in part by the release of endothelium-derived relaxing factors (EDRF). Because L-arginine may be a precursor for EDRF synthesis, we studied the pulmonary vasodilating effects of L-arginine at rest and during pulmonary hypertension in 16 intact newborn lambs. At rest, the intravenous infusions of L-arginine (150 mg/kg) had no hemodynamic effects. However, during pulmonary hypertension induced by hypoxia or the infusion… CONTINUE READING

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