L-735,524: an orally bioavailable human immunodeficiency virus type 1 protease inhibitor.

@article{Vacca1994L735524AO,
  title={L-735,524: an orally bioavailable human immunodeficiency virus type 1 protease inhibitor.},
  author={Joe P Vacca and Bruce D. Dorsey and William A. Schleif and Rhonda B Levin and Staci McDaniel and Paul L. Darke and J A Zugay and Julio C{\'e}sar Quintero and Olga M. Blahy and Elizabeth Rőth},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1994},
  volume={91 9},
  pages={4096-100}
}
To date, numerous inhibitors of the human immunodeficiency virus type 1 protease have been reported, but few have been studied extensively in humans, primarily as a consequence of poor oral bioavailability in animal models. L-735,524 represents a class of human immunodeficiency virus type 1 protease inhibitors, termed hydroxyaminopentane amides, that… CONTINUE READING