L-735,334, a novel sesquiterpenoid potassium channel-agonist from Trichoderma virens.

@article{Lee1995L735334AN,
  title={L-735,334, a novel sesquiterpenoid potassium channel-agonist from Trichoderma virens.},
  author={Seung Ho Lee and Otto D. Hensens and Gregory L Helms and Jerrold M. Liesch and Deborah L. Zink and Robert A. Giacobbe and Gerald F Bills and S Stevens-Miles and M. L. Garcia and William A Schmalhofer},
  journal={Journal of natural products},
  year={1995},
  volume={58 12},
  pages={1822-8}
}
A novel oleic acid ester of the carotane sesquiterpene 14-hydroxy CAF-603 was isolated from Trichoderma virens grown in a solid brown rice-based medium, a solid millet-based medium, or a mannitol-based liquid medium. Its structure was determined on the basis of ms and nmr analysis. It retains distinct biological activity on the high conductance calcium-activated potassium channel, unlike its analogues 14-hydroxy CAF-603, CAF-603 3-oleate, or CAF-603 3-linoleate.