L-3,4-Dihydroxyphenylalanine as a neurotransmitter candidate in the central nervous system.

@article{Misu2003L34DihydroxyphenylalanineAA,
  title={L-3,4-Dihydroxyphenylalanine as a neurotransmitter candidate in the central nervous system.},
  author={Yoshimi Misu and Kunio Kitahama and Yoshio Goshima},
  journal={Pharmacology & therapeutics},
  year={2003},
  volume={97 2},
  pages={
          117-37
        }
}
Historically, 3,4-dihydroxyphenylalanine (DOPA) has been believed to be an inert amino acid that alleviates the symptoms of Parkinson's disease by its conversion to dopamine via the enzyme aromatic L-amino acid decarboxylase. In contrast to this generally accepted idea, we propose that DOPA itself is a neurotransmitter and/or neuromodulator, in addition to being a precursor of dopamine. Several criteria, such as synthesis, metabolism, active transport, existence, physiological release… CONTINUE READING
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