L-2-amino-4-phosphonobutyrate (L-AP4) is an agonist at the type iv metabotropic glutamate receptor which is negatively coupled to adenylate cyclase

@article{Thomsen1992L2amino4phosphonobutyrateI,
  title={L-2-amino-4-phosphonobutyrate (L-AP4) is an agonist at the type iv metabotropic glutamate receptor which is negatively coupled to adenylate cyclase},
  author={C. Thomsen and P. Kristensen and E. Mulvihill and B. Haldeman and P. Suzdak},
  journal={European Journal of Pharmacology},
  year={1992},
  volume={227},
  pages={361-362}
}
Abstract Glutamate and L-AP4 inhibited forskolin-stimulated cyclic AMP (cAMP) production in baby hamster kidney (BHK) cells transfected with the type IV metabotropic receptor (mGluR4). In situ hybridization revealed a high level of mRNA for the mGluR4 in the entorhinal cortex, but not in the dentate gyrus. These data demonstrate that mGluR4 receptors arc negatively coupled to the cAMP cascade, and suggest that the mGluR4 receptor may be the previously described presynaptic L-AP4 receptor. 
The L-AP4 receptor.
  • C. Thomsen
  • Biology, Medicine
  • General pharmacology
  • 1997
Metabotropic glutamate receptors in brain function and pathology.
...
1
2
3
4
5
...

References

SHOWING 1-8 OF 8 REFERENCES
L-AP4 inhibits calcium currents and synaptic transmission via a G- protein-coupled glutamate receptor
  • P. Trombley, G. Westbrook
  • Biology, Medicine
  • The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1992