L-2-Oxothiazolidine-4-carboxylic acid reverses endothelial dysfunction in patients with coronary artery disease.

@article{Vita1998L2Oxothiazolidine4carboxylicAR,
  title={L-2-Oxothiazolidine-4-carboxylic acid reverses endothelial dysfunction in patients with coronary artery disease.},
  author={J. Vita and B. Frei and M. Holbrook and N. Gokce and C. Leaf and J. Keaney},
  journal={The Journal of clinical investigation},
  year={1998},
  volume={101 6},
  pages={
          1408-14
        }
}
The effective action of endothelium-derived nitric oxide (EDNO) is impaired in patients with atherosclerosis. This impairment has been attributed in part to increased vascular oxidative stress. EDNO action is improved by administration of ascorbic acid, a water-soluble antioxidant. Ascorbic acid is a potent free-radical scavenger in plasma, and also regulates intracellular redox state in part by sparing cellular glutathione. We specifically investigated the role of intracellular redox state in… Expand
N-acetylcysteine improves coronary and peripheral vascular function.
How does ascorbic acid prevent endothelial dysfunction?
  • J. M. May
  • Chemistry, Medicine
  • Free radical biology & medicine
  • 2000
On the role of vitamin C and other antioxidants in atherogenesis and vascular dysfunction.
  • B. Frei
  • Chemistry, Medicine
  • Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine
  • 1999
Glutathione reverses endothelial dysfunction and improves nitric oxide bioavailability.
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