L-152,804: orally active and selective neuropeptide Y Y5 receptor antagonist.

@article{Kanatani2000L152804OA,
  title={L-152,804: orally active and selective neuropeptide Y Y5 receptor antagonist.},
  author={A. Kanatani and A. Ishihara and H. Iwaasa and K. Nakamura and O. Okamoto and M. Hidaka and J. Ito and T. Fukuroda and D. Macneil and L. V. D. van der Ploeg and Y. Ishii and T. Okabe and T. Fukami and M. Ihara},
  journal={Biochemical and biophysical research communications},
  year={2000},
  volume={272 1},
  pages={
          169-73
        }
}
Neuropeptide Y (NPY) elicits food intake through the action of hypothalamic G-protein-coupled receptors. Previous publications indicate that the Y5 receptor may represent one of these postulated hypothalamic "feeding" receptors. Using a potent and orally available Y5 antagonist L-152,804, we evaluated the involvement of the Y5 receptor in feeding regulation. L-152,804 displaced [125I]peptide YY (PYY) binding to human and rat Y5 receptors with Ki values of 26 and 31 nM, respectively, and… Expand
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