L-[1-(13)C] Phenylalanine oxidation as a measure of hepatocyte functional capacity in end-stage liver disease.

@article{Burke1997L113CPO,
  title={L-[1-(13)C] Phenylalanine oxidation as a measure of hepatocyte functional capacity in end-stage liver disease.},
  author={Peter Ashley Burke and Jacqueline A Stack and Dirk Wagner and Dewi W. Lewis and Roger Lewin Jenkins and Robert Armour Forse},
  journal={American journal of surgery},
  year={1997},
  volume={173 4},
  pages={270-3; discussion 273-4}
}
BACKGROUND Liver disease is associated with impaired metabolism of these amino acids phenylalanine and tyrosine. Decreased metabolism of these amino acids leads to abnormal plasma elevations and impaired clearance rates. We have developed a noninvasive breath test that measures hepatic cytosolic enzyme activity. METHODS The rate of hepatic phenylalanine metabolism was quantitatively calculated from the appearance of 13CO2 in the breath using the nonradioactive tracer L-[1-(13)C]phenylalanine… CONTINUE READING
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