L‐phenylalanine selectively depresses currents at glutamatergic excitatory synapses

@article{Glushakov2003LphenylalanineSD,
  title={L‐phenylalanine selectively depresses currents at glutamatergic excitatory synapses},
  author={Alexander V. Glushakov and Donn M. Dennis and Colin Sumners and Christoph N. Seubert and Anatoly E. Martynyuk},
  journal={Journal of Neuroscience Research},
  year={2003},
  volume={72}
}
To explore the hypothesis that L‐phenylalanine (L‐Phe) depresses glutamatergic synaptic transmission and thus contributes to brain dysfunction in phenylketonuria (PKU), the effects of L‐Phe on spontaneous and miniature excitatory postsynaptic currents (s/mEPSCs) in rat and mouse hippocampal and cerebrocortical cultured neurons were studied using the patch‐clamp technique. L‐Phe depressed the amplitude and frequency of both N‐methyl‐D‐aspartate (NMDA) and non‐NMDA components of glutamate… 
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