L‐citrulline provides a novel strategy for treating chronic pulmonary hypertension in newborn infants

@article{Fike2014LcitrullinePA,
  title={L‐citrulline provides a novel strategy for treating chronic pulmonary hypertension in newborn infants},
  author={C. Fike and M. Summar and J. Aschner},
  journal={Acta Paediatrica},
  year={2014},
  volume={103}
}
Effective therapies are urgently needed for infants with forms of pulmonary hypertension that develop or persist beyond the first week of life. The L‐arginine nitric oxide (NO) precursor, L‐citrulline, improves NO signalling and ameliorates pulmonary hypertension in newborn animals. In vitro studies demonstrate that manipulating L‐citrulline transport alters NO production. 
The Use of Citrulline for Pediatric Pulmonary Hypertension
Arginine Therapy for Lung Diseases
Potential Nutrients for Preventing or Treating Bronchopulmonary Dysplasia.
...
1
2
3
...

References

SHOWING 1-10 OF 66 REFERENCES
Nitric oxide deficiency in pulmonary hypertension: Pathobiology and implications for therapy
L-Arginine: Rediscovery in Progress
Nitric oxide precursors and congenital heart surgery: a randomized controlled trial of oral citrulline.
L-Citrulline Attenuates Arrested Alveolar Growth and Pulmonary Hypertension in Oxygen-Induced Lung Injury in Newborn Rats
L-Citrulline ameliorates chronic hypoxia-induced pulmonary hypertension in newborn piglets.
Systemic hypertension in two patients with ASL deficiency: a result of nitric oxide deficiency?
L-Arginine therapy in cardiovascular pathologies: beneficial or dangerous?
  • R. Böger
  • Medicine
  • Current opinion in clinical nutrition and metabolic care
  • 2008
Looking beyond PPHN: The Unmet Challenge of Chronic Progressive Pulmonary Hypertension in the Newborn
...
1
2
3
4
5
...