Kynurenines in the CNS: recent advances and new questions

@article{Vcsei2013KynureninesIT,
  title={Kynurenines in the CNS: recent advances and new questions},
  author={L{\'a}szl{\'o} V{\'e}csei and Levente Szalardy and Ferenc F{\"u}l{\"o}p and J{\'o}zsef Toldi},
  journal={Nature Reviews Drug Discovery},
  year={2013},
  volume={12},
  pages={64-82}
}
Various pathologies of the central nervous system (CNS) are accompanied by alterations in tryptophan metabolism. The main metabolic route of tryptophan degradation is the kynurenine pathway; its metabolites are responsible for a broad spectrum of effects, including the endogenous regulation of neuronal excitability and the initiation of immune tolerance. This Review highlights the involvement of the kynurenine system in the pathology of neurodegenerative disorders, pain syndromes and autoimmune… 
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