Kynurenines and oxidative status are independently associated with thrombomodulin and von Willebrand factor levels in patients with end-stage renal disease.

@article{Pawlak2009KynureninesAO,
  title={Kynurenines and oxidative status are independently associated with thrombomodulin and von Willebrand factor levels in patients with end-stage renal disease.},
  author={Krystyna Pawlak and Tomasz Domaniewski and Michal C Myśliwiec and Dariusz Pawlak},
  journal={Thrombosis research},
  year={2009},
  volume={124 4},
  pages={
          452-7
        }
}
INTRODUCTION Increased oxidative stress (SOX) is one of the most potent inductors of endothelial dysfunction in end-stage renal disease (ESRD) patients. Kynurenines are the metabolites of tryptophan (TRP) degradation in mammals. However, the role of kynurenines in the function of the endothelium is still not recognized. MATERIALS AND METHODS We determined the plasma concentrations of TRP, kynurenine (KYN), 3-hydroxykynurenine (3-HKYN), quinolinic acid (QA); markers of SOX: Cu/Zn superoxide… CONTINUE READING
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