Kynurenines and headache

@article{Prdutz2011KynureninesAH,
  title={Kynurenines and headache},
  author={{\'A}rp{\'a}d P{\'a}rdutz and Annam{\'a}ria Fejes and Zsuzsanna Boh{\'a}r and Lilla Tar and J{\'o}zsef Toldi and L{\'a}szl{\'o} V{\'e}csei},
  journal={Journal of Neural Transmission},
  year={2011},
  volume={119},
  pages={285-296}
}
In parallel to serotonin synthesis, the major route of tryptophan catabolism is the kynurenine pathway, which produces neuroactive metabolites. Among these substances, kynurenic acid has potential neuroprotective action blocking glutamate release and glutamatergic neurotransmission. Glutamate is a key player in migraine pathogenesis; it is crucial in the communication of first and second-order neurons, and it has an important role in the genesis of cortical spreading depression, which is the… CONTINUE READING
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