Kynurenines, neurodegeneration and Alzheimer’s disease

  title={Kynurenines, neurodegeneration and Alzheimer’s disease},
  author={Zsigmond Tam{\'a}s Kincses and J{\'o}zsef Toldi and L{\'a}szl{\'o} V{\'e}csei},
  booktitle={Journal of cellular and molecular medicine},
Alzheimer's disease (AD) is one of the major causes of dementia. The pathogenesis of the disease is not entirely understood, but the amyloid β peptide (Aβ) and the formation of senile plaques seem to play pivotal roles. Oligomerization of the Aβ is thought to trigger a cascade of events, including oxidative stress, glutamate excitotoxicity and inflammation. The kynurenine (KYN) pathway is the major route for the metabolism of the essential amino acid tryptophan. Some of the metabolites of this… CONTINUE READING


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Oxidative stress increases expression and © 2010 The Authors Journal compilation © 2010 Foundation for Cellular and Molecular Medicine/Blackwell Publishing

  • E Tamagno, P Bardini, A Obbili
  • Ltd J. Cell. Mol. Med
  • 2010
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