Kynurenine pathway metabolic balance influences microglia activity: Targeting kynurenine monooxygenase to dampen neuroinflammation

@article{Garrison2018KynureninePM,
  title={Kynurenine pathway metabolic balance influences microglia activity: Targeting kynurenine monooxygenase to dampen neuroinflammation},
  author={Allison M Garrison and Jennifer M. Parrott and Arnulfo Tu{\~n}on and J. Delgado and Jason C. O’Connor},
  journal={Psychoneuroendocrinology},
  year={2018},
  volume={94},
  pages={1-10}
}
Chronic stress or inflammation increases tryptophan metabolism along the kynurenine pathway (KP), and the generation of neuroactive kynurenine metabolites contributes to subsequent depressive-like behaviors. Microglia regulate KP balance by preferentially producing oxidative metabolites, including quinolinic acid. Research has focused on the interplay between cytokines and HPA axis-derived corticosteroids in regulating microglial activity and effects of KP metabolites directly on neurons… CONTINUE READING