Kynurenine 3-Monooxygenase Inhibition in Blood Ameliorates Neurodegeneration

Abstract

Metabolites in the kynurenine pathway, generated by tryptophan degradation, are thought to play an important role in neurodegenerative disorders, including Alzheimer's and Huntington's diseases. In these disorders, glutamate receptor-mediated excitotoxicity and free radical formation have been correlated with decreased levels of the neuroprotective… (More)
DOI: 10.1016/j.cell.2011.05.020

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