Kynurenic acid synthesis in cerebral cortical slices of rats with progressing symptoms of thioacetamide-induced hepatic encephalopathy.

@article{Saran2004KynurenicAS,
  title={Kynurenic acid synthesis in cerebral cortical slices of rats with progressing symptoms of thioacetamide-induced hepatic encephalopathy.},
  author={Tomasz Saran and Wojciech Hilgier and Ewa M. Urbańska and Waldemar Andrzej Turski and Jan Albrecht},
  journal={Journal of neuroscience research},
  year={2004},
  volume={75 3},
  pages={436-40}
}
Increased ammonia is a major pathogenic factor in hepatic encephalopathy (HE), a neurologic syndrome associated with glutamatergic dysfunction. Previous studies have shown that in rat cerebral cortical slices or a glia-derived cell line, acute treatment with ammonia in vitro and in vivo inhibits the production of a broad-spectrum antagonist of excitatory amino acid receptors, kynurenic acid (KYNA). The present study analyzed KYNA synthesis in cerebral cortical slices obtained from rats with… CONTINUE READING
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