Kynurenic acid enhances electroacupuncture analgesia in normal and carrageenan-injected rats.

@article{Zhang2003KynurenicAE,
  title={Kynurenic acid enhances electroacupuncture analgesia in normal and carrageenan-injected rats.},
  author={Yu-qui Zhang and Guang-Chen Ji and Gen-Cheng Wu and Zhi-qi Zhao},
  journal={Brain research},
  year={2003},
  volume={966 2},
  pages={300-7}
}
The interaction between electroacupuncture (EA) and an intrathecally administered wide-spectrum excitatory amino acid (EAA) receptor(s) antagonist, kynurenic acid (KYNA) on carrageenan-induced thermal hyperalgesia and spinal Fos expression was investigated. Intrathecal (i.t.) injection of 0.1, 1, 10, and 100 nmol KYNA markedly and dose-dependently increased the latency of paw withdrawal (PWL) of the carrageenan-injected paw. While the PWLs of the non-injected and normal saline (NS)-injected… CONTINUE READING