Kynurenic acid attenuates NMDA-induced pial arteriolar dilation in newborn pigs

@article{Bari2006KynurenicAA,
  title={Kynurenic acid attenuates NMDA-induced pial arteriolar dilation in newborn pigs},
  author={Ferenc Bari and Krisztina Nagy and Paolo Guidetti and Robert M. Schwarcz and Ferenc Domoki},
  journal={Brain Research},
  year={2006},
  volume={1069},
  pages={39-46}
}
The excitatory amino acid glutamate is a potent vasodilator in the central nervous system. Glutamate-induced vasodilation is mediated primarily by N-methyl-D-aspartate (NMDA) and AMPA/kainate (KAIN) receptors. We have now tested whether two metabolites of the kynurenine pathway of tryptophan degradation acting at the NMDA receptor, the antagonist kynurenic acid (KYNA) and the agonist quinolinic acid (QUIN), are capable of modulating the dilation of pial arterioles. The closed cranial window… CONTINUE READING
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