Kynurenic acid as a ligand for orphan G protein-coupled receptor GPR35.

  title={Kynurenic acid as a ligand for orphan G protein-coupled receptor GPR35.},
  author={Jinghong Wang and Nicole Simonavicius and Xiaosu Wu and Gayathri Swaminath and Jeff D. Reagan and Hui Tian and Lei Ling},
  journal={The Journal of biological chemistry},
  volume={281 31},
Local catabolism of the essential amino acid tryptophan is considered an important mechanism in regulating immunological and neurological responses. The kynurenine pathway is the main route for the non-protein metabolism of tryptophan. The intermediates of the kynurenine pathway are present at micromolar concentrations in blood and are regulated by inflammatory stimuli. Here we show that GPR35, a previously orphan G protein-coupled receptor, functions as a receptor for the kynurenine pathway… CONTINUE READING
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Kynurenic Acid as a Ligand for GPR35 22028 JOURNAL OF BIOLOGICAL CHEMISTRY VOLUME

  • S. Okumura, H. Baba, +5 authors K. Ikenaka
  • Cancer Sci
  • 2004

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