Kynurenic acid antagonists and kynurenine pathway inhibitors.

  • Trevor W Stone
  • Published 2001 in Expert opinion on investigational drugs


The kynurenine pathway accounts for the metabolism of around 80% of non-protein tryptophan metabolism. It includes both an agonist (quinolinic acid) at NMDA receptors and an antagonist (kynurenic acid). Since their discovery, there has been a major development of kynurenic acid analogues as neuroprotectants for the treatment of stroke and neurodegenerative… (More)


Cite this paper

@article{Stone2001KynurenicAA, title={Kynurenic acid antagonists and kynurenine pathway inhibitors.}, author={Trevor W Stone}, journal={Expert opinion on investigational drugs}, year={2001}, volume={10 4}, pages={633-45} }