Kynurenic Acid in Brain and Cerebrospinal Fluid of Fetal, Newborn, and Adult Sheep and Effects of Placental Embolization

@article{Walker1999KynurenicAI,
  title={Kynurenic Acid in Brain and Cerebrospinal Fluid of Fetal, Newborn, and Adult Sheep and Effects of Placental Embolization},
  author={David W Walker and Belinda Curtis and Brendan Lacey and Ilias Nitsos},
  journal={Pediatric Research},
  year={1999},
  volume={45},
  pages={820-826}
}
Concentrations of the endogenous glutamate receptor antagonist kynurenic acid (KA) were measured in various brain regions and in cisternal cerebrospinal fluid of fetal, newborn, and adult sheep. KA concentrations were significantly higher in the fetal brain and cerebrospinal fluid at 90 and 140 d gestation compared with postnatal ages. In fetuses of 132-139 d gestation, KA concentrations in cerebrospinal fluid collected by drainage from an indwelling cisternal catheter increased significantly… CONTINUE READING

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