Kyasanur forest disease: an epidemiological view in India

@article{Pattnaik2006KyasanurFD,
  title={Kyasanur forest disease: an epidemiological view in India},
  author={Priyabrata Pattnaik},
  journal={Reviews in Medical Virology},
  year={2006},
  volume={16}
}
Kyasanur forest disease (KFD) was first recognised as a febrile illness in the Shimoga district of Karnataka state of India. The causative agent, KFD virus (KFDV), is a highly pathogenic member in the family Flaviviridae, producing a haemorrhagic disease in infected human beings. KFD is a zoonotic disease and has so far been localised only in a southern part of India. The exact cause of its emergence in the mid 1950s is not known. A variant of KFDV, characterised serologically and genetically… 
Kyasanur Forest Disease in India: innovative options for intervention
TLDR
The administration of an indigenous, inactivated tissue culture vaccine was found to drastically decrease the percentage of incidence; however, the recurrence of KFD in vaccinated subjects warrants innovative strategies for effective control of the infection.
Recent Scenario of Emergence of Kyasanur Forest Disease in India and Public Health Importance
TLDR
KFD virus has a wide range of tick vector species and involves several mammalian hosts, and it is important to consider the high prevalence of the vectors namely ticks; small mammals, monkeys, and domestic animals that are carriers of infected ticks as well as deforestation.
Kyasanur forest disease: a rare viral hemorrhagic disease in India
TLDR
There is no specific treatment for KFD but a timely supportive therapy reduces the mortality in human being, and local villagers staying in and around the forest area frequently visit the forest for collection of fire woods, grass and get infected through tick bites.
Kyasanur forest disease.
Clinical & epidemiological significance of Kyasanur forest disease
TLDR
There is an urgent need for research on KFD, particularly for understanding biphasic nature of illness, development of cost-effective diagnostic tools, utility of non-invasive samples for diagnosis and development of new vaccines.
A TICK BORN VIRAL DISEASES: KYASANUR FOREST DISEASE AND CRIMEAN-CONGO HAEMORRHAGIC FEVER IN INDIA
TLDR
There is a need for improved diagnostic facilities, more containment laboratories, better public awareness, and implementation of thorough tick control in affected areas during epidemics.
Kyasanur Forest Disease and Alkhurma Hemorrhagic Fever Virus—Two Neglected Zoonotic Pathogens
TLDR
This review aims to bring attention to the potential public health threats posed by KFDV and AHFV and highlight the urgent need for the development of effective countermeasures.
Bioinformatics characterization of envelope glycoprotein from Kyasanur Forest disease virus
TLDR
The study revealed that though mutations existed, there were no drastic changes in the structure or antigenicity of the E-proteins from recent outbreaks, and no correlation could be established between the mutations and detection in new geographical areas.
A REVIEW ON: KYASANUR FOREST DISEASE
TLDR
The diagnosis is made by virus isolation from blood or by serologic testing using enzymelinked immunosorbent serologic assay (ELISA), laboratory tests include Hemagglutination inhibition, immunofluroscence and neutralization test.
Spread of Kyasanur Forest Disease, Bandipur Tiger Reserve, India, 2012–2013
TLDR
Kyasanur Forest disease virus (KFDV) is unique to 5 districts in the Malnad region of Karnataka State, India, where each year during January–May, 100–500 persons are affected by the disease.
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Abstract Accumulated evidence about Kyasanur Forest disease (KFD) is reviewed in an effort to explain why outbreaks have been confined to the Sagar-Sorab area of Mysore State. India. Immunity surveys
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TLDR
Clinical, clinicopathologic, hematologic, and hemostatic features of Kyasanur Forest disease are described, particularly in relation to IgE as a cofactor in the immunopathology of KFD and possibly of other hemorrhagic fevers.
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TLDR
Analysis of structural genes, genetic distances, and evolutionary relationship indicate that ALKV and KFDV derived from a common phylogenetic ancestor and constitute two genetic subtypes of the same virus species according to current genetic criteria of classification.
Field evaluation of formalin inactivated Kyasanur forest disease virus tissue culture vaccine in three districts of Karnataka state.
TLDR
Analysis indicated that the Kyasanur forest disease (KFD) virus tissue culture vaccine has a highly significant protective effect.
Analysis of the structural protein gene sequence shows Kyasanur Forest disease virus as a distinct member in the tick-borne encephalitis virus serocomplex.
TLDR
KFD virus is a distinct member in the tick-borne flavivirus complex with characteristic protease cleavage sites, fusion peptide, signal sequences and hydrophobic transmembrane domains, and the possibility of developing recombinant virus vaccines is discussed.
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TLDR
The results of N tests indicated a high prevalence of DEN-2 (25.4%) virus, followed by Langat (17.5%), CHIK (15.3%), KFD (12%), JE (2.19%) and WN (1.8%).
Experimental Transovarial Transmission of Kyasanur Forest Disease Virus in Haemaphysalis spinigera
TLDR
L Laboratory studies with a third member of the tick-borne encephalitis complex, Kyasanur forest disease virus, and its vector Haemaphysalis spinigera are reported here.
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