Ky-2, a Histone Deacetylase Inhibitor, Enhances High-Salinity Stress Tolerance in Arabidopsis thaliana.
@article{Sako2016Ky2AH,
title={Ky-2, a Histone Deacetylase Inhibitor, Enhances High-Salinity Stress Tolerance in Arabidopsis thaliana.},
author={Kaori Sako and Jong-Myong Kim and Akihiro Matsui and Kotaro Nakamura and Maho Tanaka and Makoto Kobayashi and Kazuki Saito and Norikazu Nishino and Miyako Kusano and Teruaki Taji and Minoru Yoshida and Motoaki Seki},
journal={Plant \& cell physiology},
year={2016},
volume={57 4},
pages={
776-83
}
}Adaptation to environmental stress requires genome-wide changes in gene expression. Histone modifications are involved in gene regulation, but the role of histone modifications under environmental stress is not well understood. To reveal the relationship between histone modification and environmental stress, we assessed the effects of inhibitors of histone modification enzymes during salinity stress. Treatment with Ky-2, a histone deacetylase inhibitor, enhanced high-salinity stress tolerance…
37 Citations
Histone Deacetylase Inhibitor SAHA Improves High Salinity Tolerance Associated with Hyperacetylation-Enhancing Expression of Ion Homeostasis-Related Genes in Cotton
- BiologyInternational journal of molecular sciences
- 2020
Chromatin immunoprecipitation and chromatin accessibility coupled with real time quantitative PCR analyses showed that the upregulation of the ion homeostasis-related genes was associated with the elevated acetylation levels of H3K9 and H4K5 and increased Chromatin accessibility on the promoter regions of these genes.
Transcriptomic analysis of Arabidopsis thaliana plants treated with the Ky-9 and Ky-72 histone deacetylase inhibitors
- BiologyPlant signaling & behavior
- 2018
ABSTRACT Histone acetylation plays a pivotal role in plant growth and development, and is regulated by the antagonistic relationship between histone acetyltransferase (HAT) and histone deacetylase…
Transcriptome Analysis of the Hierarchical Response of Histone Deacetylase Proteins That Respond in an Antagonistic Manner to Salinity Stress
- BiologyFront. Plant Sci.
- 2019
Results indicate that deficiency in HDA19 has a bigger impact on salinity stress response than in class II HDACs, and raises the possibility that a drastic change in the homeostasis of phytohormones may contribute to increasing stress tolerance in hda19-3 and quint plants.
The Distinct Roles of Class I and II RPD3-Like Histone Deacetylases in Salinity Stress Response1[OPEN]
- Environmental Science, BiologyPlant Physiology
- 2017
It is demonstrated that class I HDAC (HDA19) and class II HDACs (Hda5/14/15/18) control responses to salt stress through different pathways, and these results provide insight into the hierarchal regulation of environmental stress responses through HDAC isoforms.
The Histone Deacetylase Inhibitor Suberoylanilide Hydroxamic Acid Alleviates Salinity Stress in Cassava
- Environmental ScienceFront. Plant Sci.
- 2017
The results suggest that epigenetic manipulation might enhance tolerance to high salinity stress in cassava, and the HDAC inhibitor, suberoylanilide hydroxamic acid (SAHA), is used for this purpose.
Regulation and Modification of the Epigenome for Enhanced Salinity Tolerance in Crop Plants
- Biology
- 2018
A perspective on the potential use of chemical epigenetic modifiers, which function as histone deacetylase (HDAC) inhibitors, for enhancing stress tolerance in crops such as cassava is provided.
HDAC inhibitor affects soybean miRNA482bd expression under salt and osmotic stress.
- BiologyJournal of plant physiology
- 2020
Histone Modifications and Chromatin Remodelling in Plants in Response to Salt Stress.
- BiologyPhysiologia plantarum
- 2021
This review has summarised the currently available knowledge on histone modifications and chromatin remodelling in relation to plant responses to salt stress and revealed the functional importance of chromatin modifiers in regulating salt tolerance and identified the effector genes affected by epigenetic modifications.
Histone Acetylation Dynamics Integrates Metabolic Activity to Regulate Plant Response to Stress
- BiologyFront. Plant Sci.
- 2019
This work proposes a model of interplay between metabolism and epigenetic regulation of genes expression in plant adaptation to stress and summarizes recent advance in the field.
Ethanol Enhances High-Salinity Stress Tolerance by Detoxifying Reactive Oxygen Species in Arabidopsis thaliana and Rice
- Environmental ScienceFront. Plant Sci.
- 2017
It is revealed that ethanol enhances high-salinity stress tolerance in Arabidopsis thaliana and rice by detoxifying ROS, and these findings may have implications for improving salt-stress tolerance of agriculturally important field-grown crops.
References
SHOWING 1-10 OF 34 REFERENCES
Involvement of Arabidopsis histone deacetylase HDA6 in ABA and salt stress response
- Environmental Science, BiologyJournal of experimental botany
- 2010
It is indicated that HDA6-involved histone modifications modulate seed germination and the salt stress response, as well as ABA- and salt stress-induced gene expression in Arabidopsis.
Chromatin changes in response to drought, salinity, heat, and cold stresses in plants
- Biology, Environmental ScienceFront. Plant Sci.
- 2015
Recent progress on the regulation and alteration of histone modification in response to the abiotic stresses, drought, high-salinity, heat, and cold in plants is summarized.
Role of histone deacetylases HDA6 and HDA19 in ABA and abiotic stress response
- Environmental SciencePlant signaling & behavior
- 2010
The study indicates that HDA6 and HDA19 may play a redundant role in modulating seed germination and salt stress response, as well as ABA- and salt Stress-induced gene expression in Arabidopsis.
Transcript Profiling in Arabidopsis Reveals Complex Responses to Global Inhibition of DNA Methylation and Histone Deacetylation*[boxs]
- BiologyJournal of Biological Chemistry
- 2005
The results indicate that global inhibition of DNA methylation or histone deacetylation has complex, nonredundant effects for the majority of responsive genes and suggest that activation of some genes requires one or more TSA-sensitive de acetylation events in addition to cytosine demethylation.
Arabidopsis stress-inducible gene for arginine decarboxylase AtADC2 is required for accumulation of putrescine in salt tolerance.
- BiologyBiochemical and biophysical research communications
- 2004
Rice histone deacetylase genes display specific expression patterns and developmental functions.
- BiologyBiochemical and biophysical research communications
- 2009
Histone acetylation associated up-regulation of the cell wall related genes is involved in salt stress induced maize root swelling
- BiologyBMC Plant Biology
- 2013
Analysis of cell morphological alterations in maize roots as a consequence of excess salinity in relation to the transcriptional and epigenetic regulation of the cell wall related protein genes suggested that the up-regulation of somecell wall related genes mediated cell enlargement to possibly mitigate the salinity-induced ionic toxicity.
Up-regulation of stress-inducible genes in tobacco and Arabidopsis cells in response to abiotic stresses and ABA treatment correlates with dynamic changes in histone H3 and H4 modifications
- Biology, Environmental SciencePlanta
- 2007
Results indicate that the quiescent BY-2 and T87 cell lines show a typical nucleosomal response to abiotic stresses and ABA treatment and may represent suitable models for the study of chromatin-mediated mechanisms of stress tolerance in plants.
Toward understanding transcriptional regulatory networks in abiotic stress responses and tolerance in rice
- Environmental ScienceRice
- 2011
A review on the rice abiotic-stress responses mediated by transcriptional networks, with the main focus on TFs that function in abiotic stress responses and confer stress tolerance in rice.
The Arabidopsis thaliana SOS2 gene encodes a protein kinase that is required for salt tolerance.
- Biology, Computer ScienceProceedings of the National Academy of Sciences of the United States of America
- 2000
Sequence analyses of sos2 mutant alleles reveal that both the N-terminal catalytic domain and the C-Terminal regulatory domain of SOS2 are functionally essential, indicating that SOS2 protein kinase activity is required for salt tolerance.






