Ky-2, a Histone Deacetylase Inhibitor, Enhances High-Salinity Stress Tolerance in Arabidopsis thaliana.

@article{Sako2016Ky2AH,
  title={Ky-2, a Histone Deacetylase Inhibitor, Enhances High-Salinity Stress Tolerance in Arabidopsis thaliana.},
  author={Kaori Sako and Jong-Myong Kim and Akihiro Matsui and Kotaro Nakamura and Maho Tanaka and Makoto Kobayashi and Kazuki Saito and Norikazu Nishino and Miyako Kusano and Teruaki Taji and Minoru Yoshida and Motoaki Seki},
  journal={Plant \& cell physiology},
  year={2016},
  volume={57 4},
  pages={
          776-83
        }
}
Adaptation to environmental stress requires genome-wide changes in gene expression. Histone modifications are involved in gene regulation, but the role of histone modifications under environmental stress is not well understood. To reveal the relationship between histone modification and environmental stress, we assessed the effects of inhibitors of histone modification enzymes during salinity stress. Treatment with Ky-2, a histone deacetylase inhibitor, enhanced high-salinity stress tolerance… 

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References

SHOWING 1-10 OF 34 REFERENCES
Involvement of Arabidopsis histone deacetylase HDA6 in ABA and salt stress response
TLDR
It is indicated that HDA6-involved histone modifications modulate seed germination and the salt stress response, as well as ABA- and salt stress-induced gene expression in Arabidopsis.
Chromatin changes in response to drought, salinity, heat, and cold stresses in plants
TLDR
Recent progress on the regulation and alteration of histone modification in response to the abiotic stresses, drought, high-salinity, heat, and cold in plants is summarized.
Role of histone deacetylases HDA6 and HDA19 in ABA and abiotic stress response
TLDR
The study indicates that HDA6 and HDA19 may play a redundant role in modulating seed germination and salt stress response, as well as ABA- and salt Stress-induced gene expression in Arabidopsis.
Transcript Profiling in Arabidopsis Reveals Complex Responses to Global Inhibition of DNA Methylation and Histone Deacetylation*[boxs]
TLDR
The results indicate that global inhibition of DNA methylation or histone deacetylation has complex, nonredundant effects for the majority of responsive genes and suggest that activation of some genes requires one or more TSA-sensitive de acetylation events in addition to cytosine demethylation.
Rice histone deacetylase genes display specific expression patterns and developmental functions.
Histone acetylation associated up-regulation of the cell wall related genes is involved in salt stress induced maize root swelling
TLDR
Analysis of cell morphological alterations in maize roots as a consequence of excess salinity in relation to the transcriptional and epigenetic regulation of the cell wall related protein genes suggested that the up-regulation of somecell wall related genes mediated cell enlargement to possibly mitigate the salinity-induced ionic toxicity.
Up-regulation of stress-inducible genes in tobacco and Arabidopsis cells in response to abiotic stresses and ABA treatment correlates with dynamic changes in histone H3 and H4 modifications
TLDR
Results indicate that the quiescent BY-2 and T87 cell lines show a typical nucleosomal response to abiotic stresses and ABA treatment and may represent suitable models for the study of chromatin-mediated mechanisms of stress tolerance in plants.
Toward understanding transcriptional regulatory networks in abiotic stress responses and tolerance in rice
TLDR
A review on the rice abiotic-stress responses mediated by transcriptional networks, with the main focus on TFs that function in abiotic stress responses and confer stress tolerance in rice.
The Arabidopsis thaliana SOS2 gene encodes a protein kinase that is required for salt tolerance.
TLDR
Sequence analyses of sos2 mutant alleles reveal that both the N-terminal catalytic domain and the C-Terminal regulatory domain of SOS2 are functionally essential, indicating that SOS2 protein kinase activity is required for salt tolerance.
...
1
2
3
4
...