Kv7.1 surface expression is regulated by epithelial cell polarization.

  title={Kv7.1 surface expression is regulated by epithelial cell polarization.},
  author={Martin Nybo Andersen and S. -P. Olesen and Hanne Borger Rasmussen},
  journal={American journal of physiology. Cell physiology},
  volume={300 4},
The potassium channel K(V)7.1 is expressed in the heart where it contributes to the repolarization of the cardiac action potential. In addition, K(V)7.1 is expressed in epithelial tissues where it plays a role in salt and water transport. Mutations in the kcnq1 gene can lead to long QT syndrome and deafness, and several mutations have been described as trafficking mutations. To learn more about the basic mechanisms that regulate K(V)7.1 surface expression, we have investigated the trafficking… CONTINUE READING