Kv2.1 ablation alters glucose-induced islet electrical activity, enhancing insulin secretion.

Abstract

Voltage-gated potassium currents (Kv), primarily due to Kv2.1 channels, are activated by glucose-stimulated pancreatic beta cell depolarization, but the exact role (or roles) of this channel in regulating insulin secretion remains uncertain. Here we report that, compared with controls, Kv2.1 null mice have reduced fasting blood glucose levels and elevated… (More)

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Cite this paper

@article{Jacobson2007Kv21AA, title={Kv2.1 ablation alters glucose-induced islet electrical activity, enhancing insulin secretion.}, author={David A Jacobson and Andrey V. Kuznetsov and James P. Lopez and Shera F Kash and Carina E Amm{\"a}l{\"a} and Louis Philipson}, journal={Cell metabolism}, year={2007}, volume={6 3}, pages={229-35} }