Kv1.5 channelopathy due to KCNA5 loss-of-function mutation causes human atrial fibrillation.

@article{Olson2006Kv15CD,
  title={Kv1.5 channelopathy due to KCNA5 loss-of-function mutation causes human atrial fibrillation.},
  author={Timothy Olson and Alexey Alekseev and Xiaoke K Liu and Sungjo Park and Leonid V. Zingman and Martin Bienengraeber and Srinivasan Sattiraju and Jeffrey D Ballew and Arshad Jahangir and Andre Terzic},
  journal={Human molecular genetics},
  year={2006},
  volume={15 14},
  pages={2185-91}
}
Atrial fibrillation is a rhythm disorder characterized by chaotic electrical activity of cardiac atria. Predisposing to stroke and heart failure, this common condition is increasingly recognized as a heritable disorder. To identify genetic defects conferring disease susceptibility, patients with idiopathic atrial fibrillation, lacking traditional risk factors, were evaluated. Genomic DNA scanning revealed a nonsense mutation in KCNA5 that encodes Kv1.5, a voltage-gated potassium channel… CONTINUE READING
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