Corpus ID: 38824239

Kv1.5-Kv beta interactions: molecular determinants and pharmacological consequences.

@article{Gonzalez2010Kv15KvBI,
  title={Kv1.5-Kv beta interactions: molecular determinants and pharmacological consequences.},
  author={T. Gonzalez and M. David and Cristina Moreno and A. Macias and C. Valenzuela},
  journal={Mini reviews in medicinal chemistry},
  year={2010},
  volume={10 7},
  pages={
          635-42
        }
}
Kv1.5 channels are homotetramers of alpha-pore subunits mainly present in human atrium and pulmonary vasculature. Thus, Kv1.5 is a pharmacological target for cardiovascular diseases. Kv beta 1.3 assemblies with Kv alpha 1.5 and modifies its gating and pharmacology. A further knowledge of alpha-beta interactions and pharmacology will lead a better design of new drugs. 
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