Kv1.3 potassium channels are localized in the immunological synapse formed between cytotoxic and target cells.

@article{Panyi2004Kv13PC,
  title={Kv1.3 potassium channels are localized in the immunological synapse formed between cytotoxic and target cells.},
  author={Gy{\"o}rgy Panyi and Gy{\"o}rgy V{\'a}mosi and Zsolt Bacs{\'o} and Mikl{\'o}s Bagd{\'a}ny and A. A. Bodnar and Zolt{\'a}n Varga and Rezső G{\'a}sp{\'a}r and L{\'a}szl{\'o} M{\'a}tyus and S{\'a}ndor Damjanovich},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2004},
  volume={101 5},
  pages={1285-90}
}
Membrane proteins of cytotoxic T cells specifically reorganize to form an immunological synapse (IS) on interaction with their specific target. In this paper, we investigated the redistribution of Kv1.3 channels, which are the dominant voltage-gated potassium channels, in the plasma membrane of allogen-activated human cytotoxic T lymphocytes (CTLs) on interacting with their specific target cells. Kv1.3 channels bearing a FLAG epitope were expressed in the CTLs and the cell-surface distribution… CONTINUE READING