Kv1.3 Channel Gene-Targeted Deletion Produces “Super-Smeller Mice” with Altered Glomeruli, Interacting Scaffolding Proteins, and Biophysics

@article{Fadool2004Kv13CG,
  title={Kv1.3 Channel Gene-Targeted Deletion Produces “Super-Smeller Mice” with Altered Glomeruli, Interacting Scaffolding Proteins, and Biophysics},
  author={Debra Ann Fadool and Kristal Tucker and Rosie Perkins and Gail Fasciani and Roger N Thompson and Arlene D. Parsons and James Michael Overton and Pandelakis A Koni and Richard A Flavell and Leonard K Kaczmarek},
  journal={Neuron},
  year={2004},
  volume={41},
  pages={389-404}
}
Mice with gene-targeted deletion of the Kv1.3 channel were generated to study its role in olfactory function. Potassium currents in olfactory bulb mitral cells from Kv1.3 null mice have slow inactivation kinetics, a modified voltage dependence, and a dampened C-type inactivation and fail to be modulated by activators of receptor tyrosine signaling cascades. Kv1.3 deletion increases expression of scaffolding proteins that normally regulate the channel through protein-protein interactions. Kv1.3… CONTINUE READING

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