Kv1.1 expression in microglia regulates production and release of proinflammatory cytokines, endothelins and nitric oxide.

Abstract

Potassium channels play an important role in microglial activation but their involvement in main functions of microglia including secretion of proinflammatory cytokines has remained uncertain. This study has revealed the specific expression of Kv1.1 in microglia both in vivo and in vitro. Kv1.1 immunoreactivity was localized in the amoeboid microglia in the… (More)
DOI: 10.1016/j.neuroscience.2008.11.043

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