Kupffer cells in the liver.

  title={Kupffer cells in the liver.},
  author={Laura J. Dixon and Mark Barnes and Hui Tang and Michele T Pritchard and Laura E Nagy},
  journal={Comprehensive Physiology},
  volume={3 2},
Kupffer cells are a critical component of the mononuclear phagocytic system and are central to both the hepatic and systemic response to pathogens. Kupffer cells are reemerging as critical mediators of both liver injury and repair. Kupffer cells exhibit a tremendous plasticity; depending on the local metabolic and immune environment, then can express a range of polarized phenotypes, from the proinflammatory M1 phenotype to the alternative/M2 phenotype. Multiple M2 phenotypes can be… CONTINUE READING