Kupffer cell-mediated cytotoxicity against hepatoma cells occurs through production of nitric oxide and adhesion via ICAM-1/CD18.

@article{Saito1996KupfferCC,
  title={Kupffer cell-mediated cytotoxicity against hepatoma cells occurs through production of nitric oxide and adhesion via ICAM-1/CD18.},
  author={Hidetugu Saito and I. Kurose and Hirotoshi Ebinuma and Dai Fukumura and Hajime Higuchi and Kazuhiro Atsukawa and Shinichiro Tada and Hiromi Kimura and Yoshikazu Yonei and Tohru Masuda and Soichiro Miura and Hiromasa Ashitani Noriaki Ishii},
  journal={International immunology},
  year={1996},
  volume={8 7},
  pages={1165-72}
}
Rat Kupffer cell (KC)-mediated cytotoxicity against both the syngeneic hepatoma cell line AH70 and hepatocytes was evaluated by changes in mitochondrial function, and the possible role of ICAM-1/CD18 in the interaction between the cells was studied. Rhodamine 123 fluorescence, a marker of the mitochondrial membrane potential, decreased in AH70 cells after… CONTINUE READING