Kupffer cell inactivation delays repair in a rat model of reversible biliary obstruction.

@article{Roggin2000KupfferCI,
  title={Kupffer cell inactivation delays repair in a rat model of reversible biliary obstruction.},
  author={Kevin King Roggin and Elaine F. Papa and Arlett G Kurkchubasche and Thomas F Tracy},
  journal={The Journal of surgical research},
  year={2000},
  volume={90 2},
  pages={166-73}
}
BACKGROUND During cholestatic liver injury, Kupffer cells (KC) and activated macrophages modulate cell proliferation and subsequent matrix deposition. The role of KC in the restoration of cell architecture and matrix metabolism during repair following chronic cholestatic liver injury is unknown. MATERIALS AND METHODS To determine the effect of KC inactivation, adult male Sprague-Dawley rats underwent bile duct suspension (BDS) for 5 days followed by reversal of the obstruction. Saline… CONTINUE READING