Ku86 is not required for protection of signal ends or for formation of nonstandard V(D)J recombination products.

@article{Han1997Ku86IN,
  title={Ku86 is not required for protection of signal ends or for formation of nonstandard V(D)J recombination products.},
  author={Jeong Ok Han and Stender Steen and David B Roth},
  journal={Molecular and cellular biology},
  year={1997},
  volume={17 4},
  pages={
          2226-34
        }
}
Ku, a heterodimer of 70- and 86-kDa subunits, serves as the DNA binding component of the DNA-dependent protein kinase (DNA-PK). Cells deficient for the 86-kDa subunit of Ku (Ku86-deficient cells) lack Ku DNA end-binding activity and are severely defective for formation of the standard V(D)J recombination products, i.e., signal and coding joints. It has been widely hypothesized that Ku is required for protection of broken DNA ends generated during V(D)J recombination. Here we report the first… CONTINUE READING
BETA

Topics from this paper.

Citations

Publications citing this paper.
SHOWING 1-10 OF 21 CITATIONS

Similar Papers

Loading similar papers…