Ku86 is essential in human somatic cells.

  title={Ku86 is essential in human somatic cells.},
  author={Gang Li and Caron Nelsen and Eric A. Hendrickson},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={99 2},
Ku86 plays a key role in nonhomologous end joining in mammals. Functional inactivation in rodents of either Ku86 or Ku70, which form the heterodimeric DNA end-binding subunit of the DNA-dependent protein kinase complex, is nevertheless compatible with viability. In contrast, no human patient has been described with mutations in either Ku86 or Ku70. This has led to the hypotheses that either these genes are performing an additional essential role(s) and/or redundant pathways exist that mask the… CONTINUE READING


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